Filling with comfort
saypha filler Lidocaine is a viscoelastic solution to correct light to moderate nasolabial folds₂₅ The ancillary role of lidocaine hydrochloride is to reduce the patient's discomfort during treatment₂₆
₂₅ Saypha Filler IFU, Indications section, lines 95–97 ₂₆ Saypha Filler IFU, Description section, lines 38–40

¹ Rzany B., Sulovsky M., Sattler G., Cecerle M., Grablowitz D., Long-term Performance and Safety of Princess volume plus Lidocaine for Midface Augmentation: The PRIMAvera Clinical Study, Aesthetic Surgery Journal, 2023;, sjad230, https://doi.org/10.1093/asj/sjad230 (Since 2018 the product range is named saypha®). ² Brandt FS, Cazzaniga A. Hyaluronic acid gel fillers in the management of facial aging. Clin Interv Aging. 2008;3(1):153-9. doi: 10.2147/cia.s2135. PMID: 18488885; PMCID: PMC2544360. ³ Wang F, Garza LA, Kang S, Varani J, Orringer JS, Fisher GJ, Voorhees JJ. In vivo stimulation of de novo collagen production caused by cross-linked hyaluronic acid dermal filler injections in photodamaged human skin. Arch Dermatol. 2007 Feb;143(2):155-63. doi: 10.1001/archderm.143.2.155. PMID: 17309996. ⁴ Instruction for use
(Patient 1)
Patient treated with saypha® filler Lidocaine for the correction of nasolabial folds with retrograde serial linear threading technique into the deep dermis. 0.2 mL per side.
(Patient 2)








